Predictors of Mortality in Acute Mesenteric Ischemia: A Systematic Review and Meta-Analysis
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- Category: Vol. 92, December 2024
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Predictors of Mortality in Acute Mesenteric Ischemia: A Systematic Review and Meta-Analysis, HOSSAM E.M.A. ELFIKI, MAHMOUD Z.A. ELGANZOURY, RAMEZ M. WAHBA and ABDELRAHMAN MAGDY AHMED
Abstract Background: Acute mesenteric ischemia (AMI) is a life-threatening medical and surgical emergency, Despite im-provement in diagnosis and a recent multidisciplinary approach, there has not been any considerable improvement in mortality in patients suffering from AMI, and the overall mortality rates are high in comparison to other surgical emergencies. Aim of Study: The aim of this review was to determine the clinical predictors of mortality in patients with acute mesenteric ischemia. Patients and Methods: The review considered case-control studies, case report studies, prospective cohort studies and ret-rospective case follow-up clinical predictors of mortality in pa-tients with acute mesenteric ischemia since 2010 till 2022 that involve patients with acute mesenteric ischemia. The follow-ing electronic databases were searched up to 2022: PubMed, Google Scholar search engine, Cochrane database of systematic reviews, EMBASE and Science Direct, Wiley Online Library, The Journal of Ankle and Foot Surgery and Clinical Key data-base searching keywords and terms listed below: “Mesenteric ischemia; acute ischemia, acute mesenteric ischemia, mortality of acute mesenteric ischemia, comorbidities with mesenteric ischemia”. Results: In our study, the Etiology of AMI was also vari-able among patients. 915 patients had arterial occlusive mes-enteric ischemia (AOMI), 354 patients had mesenteric venous thrombosis and 193 patients had non-occlusive mesenteric is-chemia (NOMI) while 7678 patients had either other secondary cause of AMI or the etiology was unspecified. In our study, age and gender were factors related to demographics included in the current review. Age was reported by 15 studies and was significantly asso-ciated with mortality (OR 1.19, 95% CI 1.09 - 1.29; p<0.00001; I2=82%). Gender was assessed in 18 studies. It was analyzed as male versus female but it could not achieve statistical signifi-cance (OR 0.96, 95% CI 0.85-1.07; p=0.46; I2=34%). Conclusion: This comprehensive review investigated clin-ical predictors of mortality in patients with acute mesenteric is-chemia (AMI) from studies conducted between 2010 and 2022.