Cyclooxygenase-2 Expression in Chronic Hepatitis, Cirrhosis and Hepatocellular Carcinoma
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- Category: Vol. 77, December 2009
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Cyclooxygenase-2 Expression in Chronic Hepatitis, Cirrhosis and Hepatocellular Carcinoma, NIHAL S. ABD EL-WAHAB ZAFER
Abstract
Background: Several studies have demonstrated the pro-tective effects of preconditioning in STEMI but it remained uncertain in patients with non STEMI.
Aim: To evaluate preconditioning in non STEMI.
Patients and Methods: 80 patients with first non-STEMI who were admitted to Ain Shams University Hospitals were divided into group one: 40 patients without preinfarction angina and group two: 40 patients with preinfarction angina and subdivided into group 2A: With preinfarction angina within 12 hours before admission and group 2B: With delayed preinfarction angina >12 hours preinfarction angina.
Methods: All patients received standard treatment for non-STEMI.ECG, cardiac enzymes, coronary angiography and informed concents were done for all patients. Echocar-diography was done to every patient before discharge.
Results: Higher myocardial biomarkers and lower LV ejection fraction was found in group 1 than group 2 (51±6.7 vs 57±6.5 respectively p-value 0.006) total CPK in group 1: 162±45 vs 680±90 in group 2 with p-value 0.016. All major cardiac events were more in group 1. Incidance of recurrent ischemia was 65% in group 1 and 30% in group 2 (p-value 0.008). Timing of preinfarction angina did not affect the inhospital outcome and did not influence myocardial protection.
Conclusion: Preinfarction angina is aprotective mechanism in patients with non STEMI regardless the timing of preinf-arction angina.