Lipid Peroxidation and Antioxidant Status in Breast Cancer Patients before and after Therapy
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- Category: Vol. 77, December 2009
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Lipid Peroxidation and Antioxidant Status in Breast Cancer Patients before and after Therapy,MOHAMAD A. EL-HEFNY, SEVIL T. KARIMOVA and ARIF M. AFANDIEV
Abstract
Breast cancer, the third most common cancer worldwide, accounts for the highest morbidity and mortality. Oxidative stress has been implicated in playing a crucial role in the pathogeneses of a number of diseases, including breast cancer. Oxidative stress occurs due to an imbalance in prooxidant and antioxidant levels. The aim of this study is to examine oxidative stress and antioxidant status in patients with breast cancer and to investigate the changes of the lipid peroxidation and antioxidant status in the blood of breast cancer patients before and after therapy. The level of malondialdehyde (MDA), as an index of lipid peroxidation, was measured. Also, the activities of superoxide dismutase (SOD) and catalase (CAT) enzymes, as well as the level of reduced glutathione (GSH) was measured in groups of preoperative breast cancer patients (n=40), 3 weeks after surgery (n=30), 3 weeks after chemo-therapy (n=30) and healthy female controls (n=35). The level of malondialdehyde (MDA) was significantly higher in all groups of breast cancer patients compared to controls (p<0.05). Similarly, antioxidant SOD in preoperative group significantly was increased (p<0.05). However, the levels of GSH and CAT activities were found significantly decreased in the all groups of breast cancer patients compared to control subjects (p<0.05). In addition, there was no significant difference between preoperative, postoperative and after chemotherapy patients. In Conclusions, a poor antioxidant status and high oxidative stress are associated with breast cancer risk. There no difference in the lipid peroxidation and antioxidant status in the blood of breast cancer patients before and after therapy. Prospective studies in a larger population should be carried out to demon-strate our present findings.