Angiotensin Converting Enzyme I/D Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus
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- Category: Vol. 77, June 2009
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Angiotensin Converting Enzyme I/D Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus,WAHEBA A. ZAROUK, IBTESSAM R. HUSSEIN, HANAN A. ABDEL REHIEM, HALA M. RASLAN, NAHED A. EMARA, MAHA A. RASHEED and MAHA EL WASSEFE
Abstract
Objective: The deletion (D) allele of the angiotensin-I converting enzyme (ACE) is associated with higher ACE activity, it has been studied in various populations in relation to hypertension and type 2 diabetes mellitus (DM) with contradictory results. The objective of this study was to determine the ACE insertion/deletion polymorphism , genotype distribution in Egyptian patients with type 2 DM and to evaluate the possible association of ACE insertion/deletion polymorphism with hypertension in diabetic patients.
Subjects and Methods: A total of 48 patients with type 2 DM, 23 of them had hypertension and 21 healthy subjects age and sex matched with the patients, as control group were included in this study. Genotyping was performed by poly-merase chain reaction (PCR).
Results: The frequency of DD genotype was significantly higher in diabetic patients compared to controls (p=0.008). The DD genotype (Vs DI and II genotypes) was associated with increased risk of diabetes (OR: 3.647, 95% CI: 1.235- 10.773, p=0.016) and the D allele was more frequent in diabetic patients and was associated with increased risk of diabetes (OR: 3.939, 95% CI: 1.782-8.709, p<0.001). No significant difference in genotype distribution or allele fre-quency was detected between diabetic patients with and without hypertension.
Conclusion: We can conclude that a significant association between ACE gene I/D polymorphism and type 2 DM is present in Egyptian patients and the D allele is associated with increased risk for type 2 DM.