Curcumin/Irbesartan Combination Improves Insulin Sensitivity and Ameliorates Diabetes- Induced Pro-Inflammatory Cytokines in Type-2 Diabetes Rat Model
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- Category: Vol. 77, June 2009
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Curcumin/Irbesartan Combination Improves Insulin Sensitivity and Ameliorates Diabetes- Induced Pro-Inflammatory Cytokines in Type-2 Diabetes Rat Model,OMAIMA M. ABD ALLAH and FOUAD EL-DEBAKEY
Abstract
Objectives: This study aimed to evaluate the impact of chronic administration of an angiotensin II receptor antagonist (Irbesartan) and/or curcumin on blood glucose level, insulin sensitivity, and proinflammatory cytokines in experimentally-induced type-2 diabetes in albino rats.
Material and Methods: The study comprised 50 male albino rats; 20 rats as control group and 30 rats were maintained on high-fat diet for 2-weeks and had induced non-insulin dependent diabetes mellitus (NIDDM) using intraperitoneal injection of a single dose of streptozotocin (STZ) in a dose of 50 mg/kg and 1-week later, rats were subdivided into three equal subgroups received oral irbesartan (2.5 mg/kg/day), oral curcumin (200 mg/kg) and both lines in that defined doses, respectively, for 6 weeks. Homeostasis Model Assess-ment of Insulin Resistance (HOMA-IR) was used for clinical assessment. Two fasting venous blood samples were obtained after induction of diabetes and prior to initiation of therapy and at 6-wks after treatment for estimation of fasting insulin (FI), fasting blood glucose (FBG), serum interleukin (IL)-1ß and IL-6 and tumor necrosis factor-a (TNF-a).
Results: Both lines of treatment either alone or in com-bination induced significant reduction of FBG and FI levels compared to their pre-treatment levels and administration of curcumin either alone or in combination with irbesartan induced significant reduction of FBG compared to irbesartan, but combination therapy significantly lower FI levels com-pared to animals received either irbesartan or curcumin alone. Post-treatment HOMA-IR indices were significantly improved in the studied subgroups compared to pre-treatment levels, with the effect was more significantly pronounced with the used combination of curcumin and irbesartan. Furthermore, post-treatment serum levels of studied cytokines were signif-icantly lower compared to pre-treatment levels, irrespective of line of treatment applied and administration of curcumin, either alone or in combination with irbesartan significantly reduced serum levels of IL-6 and TNF-a compared to irbe-sartan alone.
Correspondence to:
Dr. Omaima M. Abd Allah, Pharmacology Department, Faculty of Medicine, Benha University.
Conclusion: Chronic administration of irbesartan/curcumin combination showed anti-diabetic effect manifested as de-creased FBG and FI levels and ameliorated the increased serum levels of pro-inflammatory cytokines. The use of such combination could be recommended for clinical trials so as to document its use for control of type-2 diabetes.