Relationship of Family History with Sex and Age in Newly Diagnosed Children with Insulin Dependent Diabetes Mellitus in the Western Province of Saudi Arabia
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Relationship of Family History with Sex and Age in Newly Diagnosed Children with Insulin Dependent Diabetes Mellitus in the Western Province of Saudi Arabia,MOHAMAD ABDEL FATTAH EL-SAYED
Abstract
We aimed to determine the magnitude of positive family history (FH) of IDDM among 1st and 2nd degree relatives of newly diagnosed children with IDDM throughout 4 years study and evaluation of its relationship with sex and age in western province of Saudi Arabia.
Methods: Data were collected from medical records of 119 newly diagnosed patients with IDDM 69 females (58%) and 50 males (42) with Age ranged between 1 month and 12 years at diagnosis, who were followed-up at the outpatient endocrinology clinic throughout 4 years study from beginning of 2005 till the end of 2008. These data included sex, age at initial diagnosis, parental consanguinity and family history (FH) of other diabetic relatives of 1st, 2nd degrees including parents, siblings, uncles/aunts, cousins and grandparents. In addition, patients' clinical data suggestive of associated autoimmune disorders and FH of affected members with autoimmune disease were also looked for. Patients' historical data were obtained by a detailed questionnaire of family members; who were mostly the two parents.
Results: It was noted that females had got suffering usually at a mean of 1 year or more older than males. Moreover, it was noted that the closer the relationship of diabetic family members to the diabetic child, the earlier age at initial clinical presentation. FH of diabetic 1st degree relative (parents and siblings) with IDDM was 26.1% in females and 24% in males. Strong FH with affected more than one 1st degree relative with IDDM was reported in 7.2% of females and 8% of males. Preceding or co-incidence of one or more of autoimmune disorders was reported in 10.1% of females versus 2mal% in es. Sex differences as regard for age at initial diagnosis and family members affected with diabetes (IDDM or NIDDM) were non-significant by different statistical methods while for autoimmune disorders in the family members, it was highly significant more frequent in the female side while absent in male side.