Seroprevalance of Helicobacter Pylori Among Egyptian Patients with Hepatic Encephalopathy
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- Category: Vol. 77, June 2009
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Seroprevalance of Helicobacter Pylori Among Egyptian Patients with Hepatic Encephalopathy, MOHAMAD M. NABEEL and KHALED GAMAL
Abstract
Background: Hepatic encephalopathy is a serious compli-cation of end stage liver disease (ESLD), several theories for etiopathogenesis have been suggested, recently Helicobacter pylori (H. pylori) have been hypothesized to be correlated with the severity of hepatic encephaloptahy.
Aim: Is to assess for the prevalence of H. pylori in patients with hepatic encephalopathy and to study its correlation with severity of illness.
Methodology: 75 patients with ESLD were evaluated; 50 patients with hepatic encephalopathy and 25 patients without encephalopathy. In addition to 25 healthy subjects served as a control. Demographic data of studied patients were collected and staging of encephalopathy was done according to West Haven classification system. Seropevalence of H. pylori was evaluated by ELISA.
Results: Seroprevalence of H. pylori infection was 74% in encephalopathy group while it was 64% and 44% in patients without encephalopthy and healthy subjects respectively. Prevalence and titre of H. pylori were found significantly increasing with the severity of hepatic encephalopathy.
Conclusion: There is a significant association between H. pylori and patients of liver disease with hepatic encephal-opathy. There may be a role of anti-H. Pylori therapy in patients of hepatic encephalopathy and should be investigated further.