Treatment of Menorrhagia Associated with Uterine Leiomyoma with the Levonorgestrel-Releasing Intrauterine System
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Treatment of Menorrhagia Associated with Uterine Leiomyoma with the Levonorgestrel-Releasing Intrauterine System,OSAMA SHAWKI, WALEED EL-SHERBINY, AHMAD N. ASKALANY, WALEED SABER and ASHRAF EL-DALY
Abstract
Menorrhagia is an increasingly common health problem. The levonorgestrel-releasing intrauterine system (LNG-IUS) has been advocated for the treatment of menorrhagia as an alternative to surgery.
Based on this established indication and theoretical po-tential of targeted endometrial solution of myoma-related bleeding, we evaluated the efficiency of LNG-IUS in treating selected cases presenting with menorrhagia in the presence uterine leiomyomas.
This study included 68 patients with history of menorrhagia and U/S proved submucous uterine leiomyoma. Uterine bleed-ing was done by the semiquantitative pictorial blood loss assessment score (PBAC). The 5-Dimensional EuroQol (EQ-5D) was chosen as the primary measure of effectiveness on health-related quality of life. Patients were re-evaluated at 3,6,9 and 12 month.
After 12 months of follow-up, a significant reduction of menstrual flow was observed up to amenorrhea (in 11 cases). No significant effect for the LNG-IUS on the volume of fibroids or the uterine volume was observed. A significant improvement of the quality of life (measured by EQ index) was observed. Side effects were reported in 10 cases. Eight cases required removal of the IUD for different reasons.
So this study shows that in selected cases of uterine leiomyomas, LNG-IUS is an effective therapy directed towards the local steroid environment of the endometrium for control of the bleeding with no valuable effect on the myomas them-selves.