New Biochemical Marker in Acute Coronary Syndromes: Diagnostic and Prognostic Implications of Plasma Angiogenin
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- Category: Vol. 77, September 2009
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New Biochemical Marker in Acute Coronary Syndromes: Diagnostic and Prognostic Implications of Plasma Angiogenin, MOHAMAD T. ELKHOLY, AHMAD F. ISMAIL and IBRAHIM E. EWEES
Abstract
Acute coronary syndrome (ACS) represents a life threat-ening manifestation of atherosclerosis usually precipitated by acute thrombosis, induced by a ruptured or eroded atheroscle-rotic plaque, with or without concomitant vasoconstriction. Angiogenesis is a complex biological process that has precise coordination of multiple steps. Angiogenin is a potent angio-genic growth factor related to endothelial cell proliferation. This work tried to asses angiogenin as biochemical marker contributing to the pathophysiology of ACS and its prognostic value in adverse events of ACS. This study included 23 patients of ACS. Ten patients were in disease controls group and another twelve as healthy controls. The results revealed markedly elevated angiogenin levels in acute coronary syn-drome compared to the controls (Disease group and healthy control group) p<0.0001. No significant difference in angio-genin levels between the disease control and the healthy controls. Angiogenin was high in those patients with adverse outcomes.
In Conclusion: Plasma angiogenin levels were significantly increased in ACS. Angiogenin may be involved in the patho-genesis of ACS and may have prognostic value to predict adverse events.