Sildenafil Non-Responders: The Relation of Polymorphism ACE Gene I/D to Response to Sildenafil
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- Category: Vol. 77, September 2009
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Sildenafil Non-Responders: The Relation of Polymorphism ACE Gene I/D to Response to Sildenafil,IHAB A. OSMAN and OLFAT G. SHAKER
Abstract
Objectives: Sildenafil is the first oral phosphodiestrase-5 (PDE-5) inhibitor that revolutionized the therapeutic approach to erectile dysfunction (ED). We investigated a possible association between response to Sildenafil and an insertion/ deletion (I/D) polymorphism in the gene encoding for angio-tensin converting enzyme (ACE).
Material and Methods: A total of 60 males with ED were included in this study. Sildenafil was administered to each patient at a dose of 50 to 100mg, according to his erectile response. The drug response was measured by interviewing the patient according to the validated Arabic translation of the International Index of Erectile Function (IIEF-5) question-naire. ACE I/D genotypes were determined by polymerase chain reaction (PCR).
Results: Analysis of the response to Sildenafil revealed that 7 of 10 individuals homozygous for the ACE II genotype showed a positive erectile response after Sildenafil use and only 23 of 50D allele carriers (combined DD and DI genotypes) had a positive response.
Conclusions: Our Data suggest that ACE I/D genotypes might influence the response to Sildenafil in patients with ED.