Abnormal Menstrual Pattern and Severity of Endocrine and Metabolic Disturbances in Polycystic Ovarian Syndrome
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- Category: Vol. 78, December 2010
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Abnormal Menstrual Pattern and Severity of Endocrine and Metabolic Disturbances in Polycystic Ovarian Syndrome,KHALID A. ATWA and EMAN A. KISHK
Abstract
Objectives: The objective of this study is to evaluate of possible correlation between menstrual cycle irregularity and severity of endocrine and metabolic disorders in polycystic ovarian syndrome (PCOS).
Methods: Across section study was carried out on sixty women with PCOS diagnosed on the basis of clinical, hormonal and ultrasound parameters using the Rotterdam criteria. The subjects were divided into three groups: The hyperandrogenism and or hirsute women with regular menstrual cycles and polycystic ovaries on ultrasound (n=20), PCOS patients with oligomenorrhea (n=22) and PCOS patients with amenorrhea (n=18). Clinical, hormonal and biochemical parameters were evaluated and compared between the three groups.
Results: The PCOS patients with oligomenorrhea and amenorrhea had higher body mass index (BMI),modified Ferriman-Gallwey score (mF-G score), fasting insulin and homeostatic model assessment (HOMA) for insulin resistance than PCOS women with regular menstrual cycles (p<0.001). Hormonal parameters, LH, LH/FSH ratio and testosterone were significantly different between patients with abnormal menstrual pattern and patients with regular menstrual cycles.
Conclusion: Menstrual pattern in PCOS reflect the severity of endocrine and metabolic disorders so this clinical parameter might be a valuable instrument to estimate the degree or severity of endocrine and metabolic disorders and categorize the PCOS patients.