Antioxidants of Some Fruits and Vegetables Peels Extract and its Effects on Lipids Profile in Diabetic Rats
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- Category: Vol. 78, December 2010
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Antioxidants of Some Fruits and Vegetables Peels Extract and its Effects on Lipids Profile in Diabetic Rats,MOHAMAD SABRY ABD EL-BAKY and FATMA L. AHMED
Abstract
Some bioflavonoid compounds are associated with the prevention of chronic diseases such as cancer and hyperlipi-demia. Several studies have shown that antioxidant treatments improve markers of oxidative stress and lipid peroxidation in diabetic patients and animals. Phenolic compounds can act as antioxidants by many potential pathways such as free radical-scavenging, oxygen radical absorbance, and chelating of metal ions.
Aim: The present study was performed to evaluate anti-oxidants compounds of some fruit and vegetable peels extract (red apple, banana, red beet roots, and potatoes) and its effects on lipids profile in diabetic rats.
Methods: Extraction yield of phenolic compounds by different solvents (methanol, ethanol and diethyl ether), estimation of total phenolics, total flavonoids and total fla-vonols of red apple peels, banana peels, red beet peels and potato peels were estimated. A total of thirty male healthy rats, weighing between (200-220gm) were divided into six groups. All rats were subcutaneous injected by alloxan as 150mg/kg body weight rats to induce hyperglycemic except rats of negative control. Each group containing 5 rats. Control groups (1&2) negative and positive were fed on basal diet without supplementation. All treated diabetic groups (3,4,5,6) were fed on basal diet and administrated by gastric tube 1g/kg /day methanol extract of (apple peels methanol extract (APME), banana peels methanol extract (BPME), red beet peels methanol extract (RBPME) and potato peels methanol extract (PPME) respectively.
Results: The results found that Methanol extracts of tested sample proved that the best solvent for yield extracts of all tested solvents, also there was found a strong positive corre-lation between yield extracts of tested samples and polyphenols content. All diabetic groups administrated different methanol extract of some fruits and vegetables peels (apple APME, banana BPME, red beet RBPME and potato PPME) had significant decrease in serum glucose, Triglycerides, total cholesterol LDL-c and VLDL-c cholesterol comparing with control positive.
Conclusion: It can be concluded that administrated the extract of some fruits and vegetables peels (apple APME, banana BPME, red beet RBPME and potato PPME) modify the risk of diabetic patients and it have more potential as a health supplement rich in natural polyphenols and flavonoids.