Effect of Salvia Officinalis L. (Sage) Herbs on Osteoporotic Changes in Aged Non-Cycling Female Rats
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- Category: Vol. 78, March 2010
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Effect of Salvia Officinalis L. (Sage) Herbs on Osteoporotic Changes in Aged Non-Cycling Female Rats, INAS Z.A. ABDALLAH, HALA A.H. KHATTAB, FRANÇOIS A.R. SAWIRESS and ROKIA A.S. EL-BANNA
Abstract
The most common type of osteoporosis is bone loss associated with ovarian hormone deficiency at menopause. Sage (Salvia officinalis L.) plant, which contains flavonoid phytoestrogens, has been used to reduce menopausal symp-toms. Evidence suggests that flavonoid rich foods and bever-ages may benefit bone health. The objective of this study was to evaluate the protective effect of sage herbs water extract prepared as a tea on the progression of bone loss occurred in aged non-cycling female rats. Three groups were studied: adult normal cycling rats (control group), aged non-cycling rats (aged group) and aged non-cycling rats treated with sage tea (aged treated group). Treatment with sage tea commenced immediately after baseline bone minerals density (BMD) measurements of all rats at the left femur, left tibia and lumber vertebrae using dual energy x-ray absorptiometry (DEXA). At the end of the treatment period (2 months), BMD of the left tibia, left femur and lumber vertebrae as well as serum calcium (Ca), phosphorus (P), parathyroid hormone (PTH), estradiol, osteocalcin (OCN) and alkaline phosphatase (ALP) were examined and compared between groups. The results from this study showed that aged non-cycling female rats developed bone changes similar to those seen in osteoporotic women as indicated by a decrease in bone minerals density (BMD) of the left femur, left tibia and lumber vertebrae and by a decrease of serum Ca, P and estradiol levels and an increase of serum ALP, OCN and PTH levels. Treatment with sage tea significantly decreased the decline in BMD of the left femur and left tibia, increased serum Ca, P and estradiol levels and prevented the rise of serum ALP, OCN and PTH levels. These findings suggest that sage tea is effective in reducing bone loss occurred in aged non-cycling female rats, probably by reducing of the bone turnover via inhibition of bone resorption.