Response of Liver Function Tests to Aerobic Exercise in Patients with Type 2 Diabetes Mellitus
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- Category: Vol. 78, March 2010
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Response of Liver Function Tests to Aerobic Exercise in Patients with Type 2 Diabetes Mellitus, YASSER M. ABD EL-HAMID and AZA F. ISMAIL
Abstract
Background: The importance of aerobic exercise in the management of type 2 diabetes is well known. Liver function abnormalities are highly prevalent in diabetic patients due to high prevalence of non alcoholic steatohepatitis (NASH).
Aim of Work: To study the short term effects of light intensity exercise on liver function biochemical tests in patients with type 2 diabetes.
Subjects and Methods: Included patients were 50 type 2 diabetic patients and 20 normal controls. Diabetic patients were 20 males and 30 females, mean age was 43.9±8.6y. Mean BMI was 32.07±1.3 kg/m2. Control group consisted of 9 males and 11 females, mean age was 41.4±5.5y and mean BMI was 32.5±0.4 kg/m2. All patients and controls were subjected to light intensity bicycle based exercise for 20 minutes. A blood sample was withdrawn immediately before and immediately after exercise for assessment of serum AST, ALT, GGT, Alkaline phosphatase (Alk P), Total protein (TP) and albumin.
Results: Liver enzymes were found to be significantly higher in diabetic patients than in controls while serum albumin and total proteins were found to be significantly lower in diabetics both pre exercise and post exercise. Mean values of all liver function tests studied were found to be significantly higher post exercise in both diabetic patients and control group. Mean values of percent of changes of liver enzymes were significantly higher in control group than in diabetic patients while total proteins and albumin were found to be significantly higher in diabetic patients than in controls.
Conclusion: Light form exercise can cause immediate elevation of AST, ALT, GGT, Alkaline phosphatase, serum total proteins and albumin levels both in type 2 diabetic patients and in non diabetic subjects. No clear immediate effect of diabetes mellitus on changes of liver function tests post exercise could be detected.