Thrombophilic Genes Mutations in Women with Repeated in-Vitro Fertilization (IVF) Failure
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- Category: Vol. 78, September 2010
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Thrombophilic Genes Mutations in Women with Repeated in-Vitro Fertilization (IVF) Failure,AHMAD REZK, AMAL EDRIS, MOSSAD M. OUDA, NAGLAA FATHY and SHAIMAA MOHAMAD
Abstract
Objective: The aim of this study is to clarify the value of the aetiological diagnosis of mutation in thrombophilic genes gene, prothrombin gene and methylenetetrahydrofolate reduc-tase gene in women with repeated IVF-embryo transfer failure with unknown causes.
Methods: Women with two or more previously failed IVF-embryo transfer cycles with unknown causes were in-cluded. The control was divided into 2 groups; group A included women who conceived spontaneously with no pre-vious history of miscarriage and group B included women who have had successful pregnancy after their first IVF-embryo transfer cycle.
Results: There are high statistically significant increases in the number of patients either heterozygous or homozygous with factor V, prothrombin and methylenetetrahydrofolate reductase genes mutation in the study group.
Conclusion: These data suggest that factor V, prothrombin and methylenetetrahydrofolate reductase gene mutation may have a significant role in repeated implantation failure fol-lowing IVF/ICSI treatment cycles