B-Type Natriuretic Peptide A Biomarker for the Diagnosis and Risk Stratification of Patient with Sepsis and Septic Shock
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- Category: Vol. 79, December 2011
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B-Type Natriuretic Peptide A Biomarker for the Diagnosis and Risk Stratification of Patient with Sepsis and Septic Shock,NAEL S. AHMED, AMAL RISK, SHEREEN M. SAID and RANDA A. MOSTAFA
Abstract
Background: B-type natriuretic peptide (BNP) is a neuro-hormone released from the ventricles of the heart. The goal of this study was to examine the relationship between BNP levels and the severity of sepsis independent of congestive heart failure.
Design: Prospective, non randomized control study.
Setting: University Hospital, Critical Care Medicine Department from March 2010 to Feb. 2011.
Patients: Thirty patients were divided into 3 groups: 10 patients with severe sepsis and septic shock, 10 patients with early sepsis, and 10 age-matched healthy control subjects. We excluded patients with septic shock who had comorbid conditions (congestive heart failure or renal failure); sepsis severity was determined using the Sequential Organ Failure Assessment scoring system. Patients with sepsis were followed-up for 7 days.
Main Outcome Measures: Serum BNP levels, determined at the time of diagnosis of sepsis and on patient improvement or deterioration.
Results: Patients with septic shock had significantly higher BNP levels on admission compared with the other 2 groups (p<0. 001). Plasma BNP levels for patients with septic shock were positively correlated with Sequential Organ Failure Assessment scores and also BNP had prognostic value.
Conclusions: This study confirms the relationship between BNP level elevation and severity of sepsis independent of congestive heart failure. It also supports the utility of BNP level as a marker for mortality in septic shock.