The Protective Role of Selenium Against Oxidative Damage Induced by Cadmium in Albino Rats
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- Category: Vol. 79, December 2011
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The Protective Role of Selenium Against Oxidative Damage Induced by Cadmium in Albino Rats,HAGER AMER, HESHAM MOTTAWIE and KADRY EL-MASRY
Abstract
The protective role of selenium (Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity was investigated by monitoring the lipid peroxides, enzymatic and non enzymatic antioxidant activities.
Wistar albino rats were divided into four groups: Group I; Control group, group II; Rats given Cd (20mg Cd/kg body weight/day as CdCl2 for 4 weeks); group III; Given only Se (0.8mg Se/kg body weight/day as Na2SeO3 for 4 weeks), group IV; Given Cd+Se (in above mentioned amounts).
The results revealed that, Cd exposure resulted in increase in lipid peroxidation (LP) in serum, liver and kidney tissues. Vitamin C (Vit C) was decreased in liver & serum, whereas vitamin E (Vit E) was increased in liver, kidneys & serum of Cd exposed animals. Superoxide dismutase (SOD) and glu-tathione peroxidase (GSH-Px) activities were decreased in serum & both tissues, whereas catalase (CAT) activity was decreased in liver & serum. Glutathione S-transferase (GST) was increased in serum & both tissues.
Treatment with Se alone significantly increased liver, kidneys & serum SOD and GSH-Px activities, as well as CAT and GST activities only in liver & serum. In animals exposed to Se both the concentrations of Vit C and Vit E were increased in serum & both tissues. Cd treatment with Se resulted in reversal of oxidative stress. Our results show that Se may protect liver and kidney from Cd-induced oxidative stress by decreasing LP and altering antioxidant defense system in liver and kidneys of rats.