Comparison of Stromal CD10 Expression in Benign, Borderline and Malignant Phyllodes Tumors
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- Category: Vol. 79, June 2011
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Comparison of Stromal CD10 Expression in Benign, Borderline and Malignant Phyllodes Tumors,WAEL S. IBRAHIM
Abstract
Phyllodes tumors are group of biphasic fibroepithelial tumors of the breast of varying malignant potential, ranging from benign tumors to fully malignant sarcomas. According to the Egyptian National Cancer Institute, female malignant cases showed appreciable increase in the recent time period for breast cancer with the malignant phyllodes tumors repre-senting 0.41% of cases in the year 2003-2004. This is an immunohistochemical study to compare CD10 expression in benign, borderline and malignant phyllodes tumors, in order to highlight its diagnostic and prognostic values. This study conducted 34 Egyptian female cases of phyllodes tumors of different grades to be studied histologically and immunohis-tochemically using antibodies against CD10. The Chi square test was used to determine differences in CD10 expression between benign, borderline and malignant tumors. One way ANOVA test was used to determine whether the difference was significant. Significance was established at p<0.05. In the 24 cases of benign phyllodes tumors, only 4 cases (16.7%) showed positive CD10 reactivity. Three cases (60%) out of 5 borderline phyllodes tumors showed positive CD 10 reactivity, while 4 (80%) out of 5 cases of malignant phyllodes tumors showed positive CD10 staining. In conclusion, from these highly significant results this study suggests that there is a strong correlation between CD 10 expression and tumor grade, which could be an important observation that may have both diagnostic and prognostic implications as well as promising potential target for development of novel therapies.