Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among The Neonatal Population with Hyperbilirubinemia at Al-Galaa Teaching Maternity Hospital
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- Category: Vol. 79, June 2011
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Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among The Neonatal Population with Hyperbilirubinemia at Al-Galaa Teaching Maternity Hospital,ALI EL-GAYAR, NAGWA HAMDI, AMR EL-KHASHAB, MOHAMMED H. SALAH, WAFAA AMIN and HANAN FAROUK
Abstract
Glucose-6-PD deficiency is a common clinically signifi-cant enzyme defect, causing severe indirect hyperbilirubinemia in neonates.
Patients and Methods: A total of 324 term neonates with hyperbilirubinemia were screened for G6PD-deficiency, from January to December 2010. The conversion of nicotinamide adenine dinucleotide phosphate to its reduced form in eryth-rocytes is the basis of diagnostic testing for the deficiency.
Results: The analysis of the results indicated that 10 (3.35%) neonates with indirect hyperbilirubinemia were G6PD-deficient. No statistically significant difference was detected between G6PD-deficient and non-G6PD deficiency groups in relation to the time of onset of jaundice, reticulocyte count, hematocrit level, serum bilirubin at admission and maximum serum bilirubin level. Phototherapy duration, dura-tion of hospitalization and the need for exchange transfusion were higher in the G6PD-deficient group.
Conclusion: From this study we conclude that G6PD deficiency is a common enzyme defect in our neonatal popu-lation, which need early screening to provide the appropriate early management.