Role of Some Phytochemicals in the Treatment of Bronchial Asthma
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- Category: Vol. 79, June 2011
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Role of Some Phytochemicals in the Treatment of Bronchial Asthma,HESHAM MOTTAWIE, ATEF IBRAHIEM and HAGER AMER
Abstract
Purpose: In this study we investigate the role of some phytochemicals was investigate such as parsley, rosemary and thyme and its active materials vit C, rosemarinic acid and thymol respectively in the prevention or treatment of bronchial asthma.
Methods: This study was carried out on eighty rats. Rats were randomly divided into 8-groups. Group (1) control group (received water); groups from 2-8 were immunized to induced asthma then group (3) received water extract of Rosemary in a dose (200mg/kg b.wt); group (4) received water extract of Parsley in a dose (20mg/kg b.wt ); group (5) received water extract of Thyme, in a dose (0.06g/kg b.wt); groups 6,7 and 8 rats were received oral dose of Rosemarinic acid, vit C and Thymol consequently (50mg/kg b.wt, 20mg/rats, 0.7ug/rats respectively) for two weeks.
Results: A highly significant increase in the levels of erythrocytes catalase, SOD and oxidized glutathione with a significant decrease in erythrocytes glutathione were found in asthmatic rats when compared to control rats. A significant decrease in the levels of erythrocytes catalase, SOD and oxidized glutathione with a significant increase in erythrocytes glutathione were found in asthmatic rats treated with parsley, rosemary, thyme, or vit C, rosemarinic acid and thymol. When compared with asthmatic rats without any treatment.
Conclusion: It was concluded that parsley, rosemary, thyme and its active materials such as vit C, rosemarinic acid and thymol have antioxidant property and play an important role in the treatment of bronchial asthma.