Comparative Study between Three Different Protocols for Prevention of Hypertensive Disorders Associating Pregnancy
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- Category: Vol. 79, September 2011
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Comparative Study between Three Different Protocols for Prevention of Hypertensive Disorders Associating Pregnancy,AHMED M. MAGED, GHADA ABD EL-FATTAH and ABD EL-RAHMAN A. ABD EL-RAZEK
Abstract
Objective: To compare the role of low-dose aspirin, anti-oxidants (vitamin C and E) and calcium in preventing hyper-tensive disorders of pregnancy and their maternal, fetal and neonatal sequelae.
Study Design: 400 pregnant women less than 12 weeks' gestation were divided into 4 equal groups. Group I received low-dose aspirin 75mg, group II received vitamin C 1000mg/d plus vitamin E 400mg/d, group III received calcium 1000mg/d and group IV was a control group. Each group was further divided into high and low risk patients.
Results: The rate of gestational hypertension, preeclampsia and IUGR was significantly reduced more in group I and II compared to group IV. There was a significant difference between group I and II versus group III and IV regarding development of severe pre-eclampsia. There was insignificant difference regarding GA at delivery, eclampsia, HELLP, placental abruption, neonatal deaths and congenital anomalies between all study groups.
Conclusion: Use of anti-oxidants is superior to either low-dose aspirin or calcium in reduction of the risk of gesta-tional hypertension, preeclampsia and eclampsia. Use of low-dose aspirin has better results than either anti-oxidants or calcium in reduction of the rate of severe preeclampsia, HELLP and IUGR.