Thyroid Autoantibodies as a Marker of Immunologic Disorder in Women with Unexplained Recurrent Spontaneous Abortion
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- Category: Vol. 79, September 2011
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Thyroid Autoantibodies as a Marker of Immunologic Disorder in Women with Unexplained Recurrent Spontaneous Abortion EL-DESOUKI FOUDA, M.D. ; GAMAL A. BADR, M.D. ; AHMED FATA, M.D. ; MAHMOUD HADAD, M.D. and MONA ALRAYES, M.D.
Abstract
Background: Recurrent spontaneous abortion (RSA) is one of the most frustrating and difficult areas in reproductive medicine, because the etiology is often unknown and there are few evidence-based diagnostic and treatment strategies.
This study was undertaken to estimate the incidence & potential role of thyroid autoantibodies in patients with unexplained recurrent spontaneous abortion.
Patients and Methods: This is a clinical based cross sectional study of 7 months duration. 70 women were recruited and divided into two groups; clinically euthyroid 50 women with history of unexplained recurrent spontaneous abortion with mean age 27.5 years (group I), and 20 women with no history of abortion but they have living birth as a control and their mean age was 26.8 years (group II). Both groups subjected to history, clinical examination and CBC, liver and renal function tests, serum free T3 & T4 and TSH, anti-thyroid peroxidase, anti-thyroglobulin and anti-cardiolipin (IgM & IgG).
Results: Based on thyroid function profile, both groups proved to be in euthyroid state. Group (I) with RSA expressed 34/50 (68%) positive anti-peroxidase antibody (antiTPO) versus 9/20 (45%) control, and 29/50 (58%) with RSA were found to be positive for anti- thyroglobulin antibody (anti-TG) versus 3/20 (15%) control respectively. Also the results demonstrated significant positive correlation between the serum levels of anti TG and Anti TPO in women with RSA. However the anti-TG level was positively associated with RSA irrespective to number of abortion.
Conclusion: There was association between RSA and serum anti-thyroglobulin antibody with potential underlying pathogenic mechanisms may be suggested even in presence of normal thyroid functional profile.