Angiopoietin 2 Level in Type 2 Diabetic Patients with Cardiovascular Complications
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- Category: Vol. 80, December 2012
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Angiopoietin 2 Level in Type 2 Diabetic Patients with Cardiovascular Complications,SAMIHA ABO EL-YAZEED, KARIMA Y. AHMED, LAMYAA I. AHMED, OMIMA M. ALI and NAGWA A. MOHAMED
Abstract
Introduction: Diabetic patients have an increased risk of developing cardiovascular complication and this is due in part to genetic variation that influence both glucose homeostasis and atherosclerotic lesion growth. Angiopoie2 is a secreated glycoprotein that plays acomplex role in angiogenesis and inflammation.
Objective: The aim of this study to asses and compare angiopoietin2 level in healthy and type 2 diabetic patients with and without cardiovascular complication.
Methods: The present study included 75 subjects, age rang (42-62 years), 50 of them type 2 diabetic patients and 25 healthy, age and sex matched subjects who served as control group. Diabetic patients were recruited from Internal Medicine Department in Al-Zahraa University Hospital during the period from February 2011 through November 2011. Diabetic patients were classified according to cardiovascular complications into 2 groups:
Group I: Included 25 diabetic patients with cardiovascular complications.
Group II: Included 25 diabetic patients without cardiovascular complications.
Patients with history of liver diseases, renal impairment and malignancy that interfere with angiopoiten-2 level and action were excluded from this study. All individuals were submitted to the following: Full medical history and clinical examination, Anthropometric measurement: Height and weight were measured by standard procedures to calculate body mass index (BMI), ECG and Echocardiography, Fasting blood glucose, Post prandial blood glucose, Hb A1c, liver function tests (ALT, AST, Albumin), kidney function tests (urea & creatinine), cardiac enzymes (CPK & CK-MB), lipid profile (cholesterol & triglycerides), insulin level and serum angiopoi-ten-2 level.
Results: In the present study, there is highly significant increase in serum Ang-2 level among all diabetic patients when compared to all healthy control groups. Also by com-parison between diabetic patients group I and diabetic patients group II regarding serum ang-2 level we demonstrated that more significant increase in ang-2 level in patients group I than patients group II.
Conclusion: The study concluded that angiopioten-2 serum level is higher in type 2 diabetic patients compared to control group and it increased in diabetic patients with car-diovascular complications more than diabetic patients without cardiovascular complications. Circulating Ang-2 could serve as a new marker of oxidative stress and vasculopathy.