C-Reactive Protein Level as an Inflammatory Marker in Patients with Preeclampsia
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- Category: Vol. 80, December 2012
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C-Reactive Protein Level as an Inflammatory Marker in Patients with Preeclampsia,AHMED KHAIRY, HESHAM FATHEY, KHALED ABDDALLAH and AHMED SABER
Abstract
Objective: The objective of this study was to compare plasma concentrations of C-reactive protein between pregnant patients with preeclampsia and subjects with uncomplicated pregnancy.
Subjects and Methods: We conducted a case-control study of 60 nulliparous women without preexisting medical com-plications. In this study, 30 patients with preeclampsia and 30 women with uncomplicated pregnancy were enrolled. Maternal venous plasma samples were collected before delivery for estimation of C-reactive protein levels.
Results: The mean concentration of C-reactive protein was significantly higher in preeclamptic patients than in the control group. There was a significant positive correlation between C-reactive protein levels and both systolic and diastolic blood pressures. The receiver operator characteristics curve showed that the best cutoff value for C-reactive protein concentration for diagnosis of preeclampsia was 6mg/L.
Conclusion: C-reactive protein is significantly elevated during preeclampsia and is positively correlated with the severity of hypertension.