Is there an Association between Angiotensinogen M235T Gene Polymorphism and Hypertension?
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- Category: Vol. 80, December 2012
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Is there an Association between Angiotensinogen M235T Gene Polymorphism and Hypertension?,HEMMAT E. EL HADDAD, MOHAMED S.H. GOMAA and OLFAT SHAKER
Abstract
Background and Objective: The association between angiotensinogen (M235T) gene polymorphism with hyperten-sion was reported, but the results were inconsistent. The aim of our study is to get our own results of this genetic polymor-phism in our Egyptian patients paving way for more larger studies in the future applying more correlations with more cardiovascular risks associated with hypertension.
Material and Methods: In the present study, we recruited 50 normal controls and 100 patients with essential hypertension from Internal Medicine Department for the investigation. The angiotensinogen (M235T) genotypes were determined by polymerase chain reaction followed by digestion of the prod-ucts with restriction endonuclease, PsyI.
Results: There is statistically significant associations with essential hypertension that identified for TT genotype of angiotensinogen M235T polymorphism (odds ratio at 95% CI, 3.1 (1.6-5.9), p= 0.0001). Also, as regards gender, male subjects were at 2.7 times higher odds to develop essential hypertension.
Conclusions: This study shows that angiotensinogen (M235T) polymorphism is significantly associated with the essential hypertension. These results may provide a better understanding of the pathophysiology of essential hypertension and offer possibilities for identifying patients at risk. Larger association or linkage studies are needed for a more detailed risk assessment especially if applied in large section of patients with a diversity of cardiovascular risks related to hypertension. Such studies constitute the basic nucleus for pharmacogenetic customization therapy of hypertension and associated cardio-vascular diseases.