Study of Serum C-Reactive Protein Level in Patients with COPD
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- Category: Vol. 80, December 2012
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Study of Serum C-Reactive Protein Level in Patients with COPD,ABDELSADEK H. AL-AARAG, YASSER M. ISMAEIL and AHMAD A. MOHAMMAD
Abstract
Aim of the Work: The aim of this work was to study the usefulness of serum CRP as a systemic inflammatory marker for COPD patients and to evaluate ischemic heart diseases (IHD) and smoking as potential causes of raised CRP levels in COPD.
Subjects and Methods: Forty male patients with COPD were admitted to chest department, Benha University Hospital were included in this study and 40 healthy male of the same age and sex as a control group (20 smokers and 20 non-smokers) with no history of ischemic heart diseases and with normal ventilatory function tests. The patients and controls were subjected for full clinical evaluation including a full clinical and family history, History of any other co-morbidities that may raise the C-reactive protein as ischemic heart diseases, hypertension, diabetes mellitus, tuberculosis, malignancy, hepatic cirrhosis, end-stage renal disease, rheumatoid arthritis and any systemic infection or inflammation that could be associated with increased CRP values. General & local examination, routine laboratory tests, plain chest X-ray (P.A. and lateral view), Body mass index, Pulmonary function tests (spirometry) before and after bronchodilatation, Electrocar-diography, complete blood count, liver function tests, kidney function tests and fasting blood sugar and venous blood samples for C-reactive protein measurement.
Results: The level of CRP was higher in COPD cases compared to normal controls (smokers and non smokers) and the difference between them was statistically significant (p<0.05). Also the level of CRP was proportionally related to the stage of the disease as there was a significant increase in CRP level with increasing the severity of COPD. Very severe COPD cases have higher level of CRP than severe and mod-erate cases. CRP was also raised in severe cases than moderate cases and the difference between them was highly statistically significant (p<0.01).
Conclusions: Serum CRP levels are raised in COPD patients without clinically relevant IHD and independent of cigarette smoking.