Intratympanic Versus Oral Steroids in the Mangement of Idiopathic Sudden Sensorineural Hearing Loss
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- Category: Vol. 80, June 2012
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Intratympanic Versus Oral Steroids in the Mangement of Idiopathic Sudden Sensorineural Hearing Loss,AHMED HUSSEIN, AYMAN H. SALAHELDIN and KHAIRY M. ABUL-NASR
Abstract
Objective: To study and compare the efficacy of intratym-panic steroid and oral steroid in the improvement of hearing in patients with idiopathic sudden sensorineural hearing loss (ISSHL).
Patients and Methods: This study is a prospective non-randomized comparative study done on 24 patients with sudden sensorineural hearing. These patients have normal otoscopic examination and do not have apparent causes of SSHL as detected by radiologic and laboratory investigation. There were two groups with 12 patients each: group A, which was treated with oral prednisolone, and group B, which was treated with intratympanic methyl prednisolone. Baseline pure tone audiometry (b-PTA) was done prior to treatment and was compared to the PTA taken on the 7th day (PTA-7), 14th day (PTA-14), and 30th day (PTA-30) after treatment.
Results: Group A has a mean b-PTA of 80.5±14.24 SD and PTA-30 of 47.5±9.88 SD respectively. Group B has a mean b-PTA of 81.91±17.31 SD and PTA-30 of 50.83±20.06 SD. A statistically significant difference found between b-PTA and PTA-14 and PTA-30 in both groups. A statistically significant difference was also found between b-PTA and PTA-7 in group B.
Conclusion: Intratympanic steroid leads to significant improvement of hearing that is little bit lower than oral steroids after 1month of starting treatment in patients with ISSHL. Intratympanic steroid treatment is well tolerated and relatively easy to perform with no reported complication.