A Study of the Relationship between the Blood Levels of the 8-Oxoguanine DNA Glycosylase, Smoking and Risk of Lung Cancer
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A Study of the Relationship between the Blood Levels of the 8-Oxoguanine DNA Glycosylase, Smoking and Risk of Lung Cancer,NADA EZZELDIN, AMIRA DIYAA, HOWAYDA EZZELDIN, AMAL SAAD-HUSSEIN, HEBATALLAH FAROUK and DINA M. KANDIL
Abstract
Introduction: The role of The 8-oxoguanine DNA glyco-sylase (OGG1) is to delete DNA parts that have been damaged by oxygen radicals, thus preventing lung cancer.
Objective: This work is aiming to study the relationship between the variation in the blood levels of the 8-oxoguanine DNA glycosylase (OGG1), smoking and risk of lung cancer.
Material and Methods: This study included 36 patients diagnosed as bronchogenic carcinoma, divided pathologically into 30 non small cell lung cancer (NSCLC) patients and 6 small cell lung cancer (SCLC) patients, 40 non-smoker and 40 smokers’ healthy subjects, taken as control. They were subjected to medical history taking, clinical examination, chest radiography and Quantitative RT- PCR of mRNA levels of OGG1 in blood.
Results: There was a non significant increase in the mean level of the OGG1 in the non smoker group compared to the cancer and smokers’ groups (p>0.5). There was a non statistical significant decrease in the mean value of the OGG1 in the NSCLC compared to that of SCLC (p>0.5). There was statis-tical highly significant decrease in the mean value of the OGG1 in cases of adenocarcinoma compared to that in cases of squamous cell carcinoma and SCLC (p<0.0001).
Conclusion: The decreased in the levels of OGG1 in blood could be a risk factor for lung cancer and was associated with adenocarcinoma. A substantial fraction of lung cancer cases might result from a combination of smoking and reduced OGG1 level.