Comparative Study on Renoprotective Effects of Perindopril and Telmisartan on StrepotozotocinInduced Diabetic Nephropathy in Rats
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- Category: Vol. 81, December 2013
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Comparative Study on Renoprotective Effects of Perindopril and Telmisartan on StrepotozotocinInduced Diabetic Nephropathy in Rats, HANAN T. EMAM, SAMIA M. EL SHEETY, MOHAMED T. IBRAHIM and GHADA A. ABD EL FATTAH
Abstract
Diabetic nephropathy occurs in approximately one-third of all people with diabetes and is the leading cause of renal failure in developed and developing countries. Angiotensin II plays a potent role in the initiation and progression of diabetic nephropathy by increasing glmoerular pressure and glmoerular selectivity as well as activation of fibrosis and cellular growth in the kidney. Thus, agents which can inhibit the formation of angiotensin-II like ACE inhibitors or agents that can block the action of angiotensin II such as AT 1 recptor blockers have potential role in prevention of diabetic nephr-opathy. This study was designed to evaluate and compare the reno protective effects of (ACEI) perindorpil and (ARB) telmisartan on rats with diabetic nephropathy.
Diabetic nephropathy was induced in rats by streptozotocin (STZ) 100mg/Kg/single I.P administration. Diabetic nephrop-athy rats were randomly divided into 3 groups. Diabetic nephropathy group, perindopril (6mg/kg/day) and telmisartan group (10mg/kg/day). Each drug was given orally for 8 weeks stating with STZ injection. Fasting blood glucose (FBG), advanced glycation end products (AGEPs), blood urea, serum creatinine, urine protein, tissue malondyaldehyde (MDA) and tissue reduced glutathione (RG) were measured by colo-rimetric methods. Renal tissue specimens were histopatholog-ically examined by hematoxylin & eosin staining (H & E).
Both drugs significantly reduced FBG, AGEPs, blood urea, serum creatinine, urine proteins, tissue MDA and sig-nificantly increased tissue RG. Moreover, histopahtological examination of kidney tissues showed improvement of neph-ropathy in the form of reduction of thickening and infiltration of the infalammatory cells with more superior effects of telmisartan over perindopril.