Comparative Study between Carbetocin and Syntocinon in Prevention of Postpartum Hemorrhage
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- Category: Vol. 81, June 2013
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Comparative Study between Carbetocin and Syntocinon in Prevention of Postpartum Hemorrhage,WAEL S. NOSSAIR
Abstract
Objective: Carbetocin is more effective than syntocinon in prevention of postpartum hemorrhage.
Design: Observational cohort prospective study.
Setting: Zagazig University Hospital, Obstetrics and Gynecology Department from period between Januray 2012 to November 2012.
Population: 200 patients designed to have elective CS were divided into two groups:
Group A: 100 patients with elective CS take 100mg carbitocine as single dose IV.
Group B: 100 patients with elective CS take 10mg synto-cinon as single dose IV.
Methods: The study done between Januray 2012 to No-vember 2012 at Zagazig University, Obstetics and Gynaecology Emergency Hospitals.
All patient subjected to history taking, general examina-tion, routine labolatory evaluation, ultrasound evaluation.
Inclusion criteria were; previous one or previous two CS, haemoglobn range 10-12gm/d1, no placenta praevia, single baby, average amniotic fluid.
Exclusion criteria; more than 2 CS, multifetal pregnancy, placenta praevia, polyhydramnios
Main Outcome Measures: Preoperative and postoperative evaluation of hemoglobin measurement were performed. Intraopertaive and postoperative evaluation of blood loss, uterine atony, need for another uterotonic agents, and need for blood transfuson were recoreded during 1st 24 hours after CS.
Results: The mean age of group A was 29 years, and in group B 30 years old. The subgroup 1 and 2 were equal in both groups; 50 patients in every group with previous one CS and 50 patients in both groups with previous 2 CS. The mean of hemoglobin preoperative were the same 12gm/d1, postop-erative mean of haemoglobin were 10.5gm/dl in group A and 10gm/d1 in group B. The mean amount of blood loss intraop-
eratively were 450m1 in group A and 500m1 in group B. The need for another uterotonic intraopertaively were 10 patients in group A and 12 patients in group B. The need for another uterotonic agent postoperrtively was 15 patients in group A and 16 patients in group B, in these patients uterine atony were developed. After statistical analysis of these data there were no significant differences between both groups.
Conclusions: Syntocinon is effective as carbitocine in prevention of postpartum haemorhge during elective CS. But this need more studies to evaluate the efficacy of carbitocine.