The Association between Serum Adiponectin Levels and the Severity of Coronary Artery Disease
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- Category: Vol. 81, March 2013
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The Association between Serum Adiponectin Levels and the Severity of Coronary Artery Disease, MOHAMED G. ABDELBAR, BASEM E. ENANY and AYMAN O. KHALIL
Abstract
Coronary artery disease (CAD) is the leading cause of death worldwide, and it is expected that the rate of CAD will accelerate in the next decade. In human patients, serum adiponectin and CRP levels are negatively correlated. Thus adiponectin appear to play an anti-inflammatory role in atherosclerosis.
Objectives: Evaluation of the association between serum adiponectin levels and the severity of CAD as assessed by coronary angiography.
Study design: The study included 65 patients (56 males, 9 females; mean age 54.9 years) with angiographically docu-mented significant CAD (50% stenosis). The patients were divided into three groups according to the number of vessels affected; 19 had single-vessel, 22 had two-vessel, and 24 had multiple-vessel disease. The severity of coronary lesions was assessed using the modified Gensini score. Serum adiponectin levels were measured in the CAD group and in a control group of 25 subjects (7 males, 18 females; mean age 54.5 years) who were found to have normal coronary arteries on angiog-raphy.
Results: The number of male patients and the number of smokers were significantly higher in the CAD group than in control group (p-value <0.001). There was no significant difference between the both groups as regard to mean age, prevalence of hypertension, and BMI. Patients with CAD exhibited significantly lower serum levels of adiponectin compared to the control group (3.98±1.3ug/dL vs. 13.6± 5.7u g/dL; p-value<0.001), on the other hand patients with CAD exhibited significantly higher serum levels of hs-CRP compared to the control group (5.60±3.10mg/L vs. 2.98± 2.37mg/L; p-value <0.001). Serum adiponectin levels in patients with multivessels disease were significantly lower than in patients with two vessels disease and much lower than in patients with single vessels disease. There were strong negative correlation between serum adiponectin levels and the modified Gensini score (7=0.715; p-value <0.001) and hs-CRP (7=0.682; p-value <0.001).
Conclusion: Serum adiponectin levels are decreased in CAD patients compared to controls. This decrease is more prominent with increasing levels of CAD severity, which may be a helpful in risk stratification.