Low Dose Aspirin for Improving Pregnancy Rate in Patients Undergoing IVF/ICSI
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- Category: Vol. 81, September 2013
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Low Dose Aspirin for Improving Pregnancy Rate in Patients Undergoing IVF/ICSI,HODA ABDEL AAL, EMAN SHAEER and MARWA SHARAF
Abstract
Objective: Is to determine the effects of daily administra-tion of low dose aspirin starting on day of ovum pick-up on pregnancy rate in IVF/ICSI cycles comparing it with non-users.
Study Design: Prospective randomized controlled trial. Setting: IVF Unit, Kasr El-Aini Hospital, Cairo University.
Patients: Patients undergoing IVF/ICSI trials were divided into two groups. Group A were 104 cases with daily adminis-trated oral aspirin 75mg from the day of ovum pick-up and continued until confirmation of pregnancy by ultrasonographic detection of fetal cardiac pulsations, and group B, 84 cases who did not receive aspirin during the ICSI cycle with the same follow-up as group A.
Main Outcome: Main outcome measure was clinical pregnancy rate per cycle as well as rate of miscarriage.
Results: The clinical pregnancy rate in group A (aspirin group) was 28.8% and group B (non-aspirin group) was 40.5% with no statistical significant difference between them (p=0.121). Also no statistically significant difference between both groups regarding miscarriage rate (Group A=10%, group B=23%; p=0.135) was observed.
Conclusion: Aspirin does not improve neither pregnancy rate nor miscarriage rate in IVF/ICSI.