Toll-Like Receptor 2 (TLR2) Gene Expression in Psoriasis Vulgaris and its Correlation with Vitamin D3 Serum Level before and after NB-UVB
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- Category: Vol. 81, September 2013
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Toll-Like Receptor 2 (TLR2) Gene Expression in Psoriasis Vulgaris and its Correlation with Vitamin D3 Serum Level before and after NB-UVB, DINA M. SALAMA, DALIA M. ABDEL HALIM, NOHA FAWZY and LAILA RASHED
Abstract
Background: Psoriasis is a chronic, non-contagious skin disease characterized by red, inflamed cutaneous lesions covered with silvery-white scale. Both genetic and environ-mental factors are important in the etiology of the disease. The role of Toll like receptor 2 and vitamin D3 in the patho-genesis of psoriasis needs to be clarified.
Objective: The aim of this research is to estimate the level of Toll-like receptor 2 gene expression in skin tissue of psoriasis patients and Vitamin D3 in serum of psoriasis patients and compare the results to healthy control. We also used narrow band-UVB-311 as a treatment and evaluated the same parameters in psoriasis patients before and after treatment.
Patients and Methods: Fifteen patients of psoriasis and 15 age and sex matched healthy controls were enrolled in the study. TLR2 gene expression and Vitamin D3 serum levels were estimated and compared to healthy controls. Also these parameters were estimated after 36 sessions of NB-UVB.
Resullts: There was statistically significant increase in the levels of TLR2 in psoriatic patients skin tissue compared to control (p<0.001). There was statistically significant decrease in the level of Vitamin D3 in psoriasis patients serum compared to control. After using NBUVB-311 as treatment, the level of TLR2 gene expression was significantly decreased (p<0.001) and the level of Vitamin D3 was significantly increased (p<0.001) in psoriasis patients.
Conclusion: These results provide some evidence regard-ing the role of Toll-like receptor 2 and Vitamin D3 in psoriasis and effect of NB-UVB as a modality of treatment.