Can Metformin Reduce Recurrence of Gestational Diabetes in Obese Women?
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- Category: Vol. 82, June 2014
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Can Metformin Reduce Recurrence of Gestational Diabetes in Obese Women?, ASHRAF HAMDY, MOFEED FAWZY and MOHAMED A. MOHAMED
Abstract
Objective: To evaluate the efficacy of using metformin in pregnancy on prevention of recurrence of gestational diabetes in obese women.
Methods: This is a multicentric randomized non placebo clinical trial including 91 obese women with past history of GDM women in 2 groups. 44 women in intervention group used metformin therapy during the second trimester of preg-nancy compared to 47 women in control group. Screening test for GDM were performed to all women at 12-14 week and at 24-28 week gestation to detect cases with recurrent GDM.
Results: Women in the intervention group showed a signifi-cant lower rate of recurrence of GDM in the second pregnancy compared to women in the control group (18.1% vs 53.1%, OR=0.19, 95% CI=0.07–0.5, p<0.001).
Conclusion: Using metformin in the second trimester of pregnancy can effectively reduce the recurrence of GDM in obese women.