Prognostic value of β-catenin and S100A4 in Colorectal Carcinoma
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- Category: Vol. 82, June 2014
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Prognostic value of β-catenin and S100A4 in Colorectal Carcinoma, Ahlam A. Abdel Maksoud, Nashwa M. Emara and Amal A. Hassan
Abstract
Prognostication in colon cancer almost exclusively still rests on the tumor stage. Tumor-derived markers to improve discrimination of low-and high-risk groups generally are not in use.
Aim: This study aims at assessment of the prognostic role of ß-catenin and S 100A4 in colorectal carcinoma.
Patients and Methods: This study was carried on 50 cases of formalin-fixed paraffin-embedded tissue of colorectal car-cinoma and ten normal control cases. They were graded and staged according to grading and TNM staging systems. All cases were immunohistochemically examined for ß-catenin and S 100A4.
Results: Immunohistochemical results of both ß-catenin and S 100A4 were correlated with clinicopathological variables including tumor size, location, grade, depth of invasion, stage, metastatic status and 5 year survival.
A statistically significant correlation (p<0.05) was found between the pattern of ß-catenin expression and tumor loca-tion, grade, LN metastases, distant metastasis, stage and 5-year survival of colorectal adenocarcinoma cases. However no sig-nificant correlation to size or depth of invasion (p>0.05) was found. A statistically significant correlation (p<0.05) was found between the expression of S 100A4 and LN metastases, distant metastasis, stage and overall survival of colorectal adenocarci-noma. However no significant correlation was found between its expression and other clinicopathological parameters of sex, age, tumor size, tumor differentiation, tumor location and depth of invasion (p>0.05).
Conclusion: ß-catenin and S 100A4 might be considered of the prognostic markers of colorectal carcinoma as they were as-sociated with tumor progression and poor prognosis.