Value of CD34 and CD10 Immunostaining in the Differentiation between Basal Cell Carcinoma and Trichoepithelioma
/ 0
- Details
- Category: Vol. 82, June 2014
- Hits: 1599
Value of CD34 and CD10 Immunostaining in the Differentiation between Basal Cell Carcinoma and Trichoepithelioma, MOHEBAT H. GOUDA, GHADA A. ABD EL-FATTAH and ADEL Z. EL-SAEDIY
Abstract
Purpose: Trichoepithelioma (TE) is a benign skin tumor with follicular differentiation, which is sometimes difficult to distinguish clinically and histologically from basal cell carcinoma (BCC). Both are characterized morphologically by the proliferation of basaloid cells; however, BCCs are clinically associated with a more aggressive behavior. It is important to distinguish these neoplasms for effective and appropriate therapeutic planning. The present study aims at investigating the role of CD10 & CD34 in differentiation between TE and BCC.
Patients and Methods: This study includes 30 cases of BCC and 10 cases of TE. Cases were collected from Pathology Department of Faculty of Medicine-Benha University and Egyptian National Cancer Institute (NCI) in the period 2008- 2013. CD34 and CD10 immunohistochemistry was performed in all cases and the patterns of expression were analyzed.
Results: The pattern of CD34 expression in BCC copmared to that of TE was statistically significant (p<0.05). Trichoep-ithelioma exhibited stromal expression in the immediate stromal cells adjacent to the tumor islands while in BCC, the surrounding stroma was immunoreactive to CD34 with a clear zone of negatively stained cells separating epithelial islands from the positive mesenchymal stromal cells. The pattern of CD10 expression in BCC and TE was statistically highly significant (p<0.01). Seventy percent of TE cases exhibited pure stromal cells staining while 70% of BCC cases showed staining of basaloid cells.
Conclusion: This study suggests CD10 and CD34 as useful markers for the differential diagnosis between TE and BCC with preference to CD10.