Association between Helicobacter Pylori Infection and Barrett’s Esophagus in Patients with Gastro-Esophageal Reflux Symptoms and Erosive Esophagitis
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- Category: Vol. 82, September 2014
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Association between Helicobacter Pylori Infection and Barrett’s Esophagus in Patients with Gastro-Esophageal Reflux Symptoms and Erosive Esophagitis, EHSAN HASSAN, SAHAR MAKLAD and NOUR ABDEL MAKSOOD
Abstract
Objective: Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). Helicobacter pylori infection is said to play an etiological role in gastric carcinogenesis but possible role in Barret’s esophagus remains uncertain. The aim of the study was to determine the correlation between helicobacter pylori infection in GERD patients and the development of Barret’s esophagus and or esophageal carcinoma.
Methods: Sixty patients complaining of recurrent upper gastrointestinal symptoms in the form of heart burn and reflux were included in the study. Endoscopic biopsies were taken for these patients and helicobacter pylori infection was con-firmed by histopathological examination and Giemsa stain.
Results: The study was conducted on 60 esophageal biopsies from patients complaining of various recurrent upper gastrointestinal symptoms. Esophageal H.pylori infection was found in 21 of 60 (35%) patients, 29/60 (48%) revealed chronic esophagitis with 12/29 positive H.pylori infection while 28/60 cases revealed Barrett’s esophagitis with 8/28 positive H.pylori infection and 3/60 showed invasive esophageal carcinoma with 1/3positive H.pylori infection.
Conclusion: We did not find a causal relationship between H.pylori and the development of chronic esophageal inflam-mation and Barret’s esophagus. Other co factors need to be evaluated in this context as dietary factors, drug intake or others.