Effect of BMI on Deterioration of Renal Function in Patients with Primary Glomerulonephritides
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- Category: Vol. 82, December 2014
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Effect of BMI on Deterioration of Renal Function in Patients with Primary Glomerulonephritides, MAHMOUD H. KHEDR, ADLEY KAMEL, MOEEN-UZ-ZAFAR, HASHEM MOKDAD and HALA EL-SAKA
Abstract
Objective: This was a retrospective study to determine the effect of body mass index on the deterioration of renal function in patients with primary glomerulonephritides con-firmed by renal biopsy from year 2005 to 2009 in the Qassim Region of Kingdom of Saudi Arabia.
Methods: We reviewed the patient records of all adults who underwent renal biopsies at King Fahad Special Hospital (KFSH), Buraidah, Qassim, over a 4-year period from February 2005 to February 2009. Data of a total of 116 cases were recorded in a pre-formed and validated Performa. The Data were entered in SPSS 15 and analyzed.
Results: The total number of the patients was 116, out of which 34 met the exclusion criteria. Among the remaining 82 there were 42 (51.2%) male and 40 (48.8%) females. The mean age of male was 30.2±SD 10.9 years and the mean age of female was 31.1±SD 10.9 years. Our results showed Focal segmental glomerulosclerosis FSGS in 26 (31.7%); Lupus nephritis in 22 (26.8%) patients, Membranous GN in 9 (10.98%); Minimal change GN in 7 (8.5%); Transplant Glom-erulopathy with patchy Tubulointerstitial scarring (chronic rejection) in 6 (7.3%), Acute post streptococcal GN in 5 (6.1 %); IgA nephropathy in 4 (4.88%), and Membranoprolif-erative GN in 3 (3.66%). The most common lesion in females was Lupus nephritis (55%) followed by FSGS (30%) and in males was FSGS (33.3%) followed by membranous GN (16.7%).
The mean BMI was 25.4±3kg/m2. For the males it was 26.1±5.4kg/m2 and for the females 24.2±6.2kg/m2. For the purpose of statistical calculations the patients were divided into three groups by their BMI i.e. <20; 20.1-25; >25kg/m2. The odds ratio for developing deterioration of renal function (indicated by a rise in serum creatinine) for men between the highest and the lowest BMI groups was 2.1 (1.88-2.45, p=<0.05) and 1.34 (1.21-1.55, p >0.05) for women. The effect of BMI on causing renal deterioration was most significant in FSGS with OR 1.51 (1.24-1.66, p=<0.05).
Conclusion: The results of our study indicate that higher BMI is associated with poorer renal function more significant in male patients with primary glomerulonephritides especially in FSGS.