Ethical Considerations in Clinical Trials:A Pharmaceutical Perspective
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- Category: Vol. 82, December 2014
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Ethical Considerations in Clinical Trials:A Pharmaceutical Perspective
Abstract
Aim: This study explores the potential of plant-derived phytochemThis review aims to critically evaluate the ethical landscape of human subjects research, focusing on the histori-cal context of research misconduct and its impact on contempo-rary ethical guidelines. Methods: The review examines foundational documents such as the Nuremberg Code, the Declaration of Helsinki, and the Belmont Report. It analyzes the ethical implications of large, investigator-initiated randomized clinical trials (RCTs), including issues surrounding informed consent, placebo use, and participant welfare. Results: The review highlights the tension between par-ticipant safety and the advancement of medical knowledge, particularly in the context of RCTs. It discusses the complexi-ties introduced by targeted therapies in oncology, emphasizing ethical considerations related to participant selection, treatment efficacy, and distributive justice. Conclusion: The evolving ethical framework must prior-itize patient welfare while facilitating scientific progress. Ongo-ing dialogue among researchers, ethicists, and stakeholders is essential for refining ethical standards to enhance trust in bio-medical research and ensure responsible conduct.