Epidemiology of PRA in Pre Transplant Renal Recipients and its Relation to Different Factors
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- Category: Vol. 82, March 2014
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Epidemiology of PRA in Pre Transplant Renal Recipients and its Relation to Different Factors, USAMA MOHAMADY, IHAB ABDELRAHMAN, KARIM M. SOLIMAN, DAWLAT A. BELAL and MERVAT ELANSARY
Abstract
Background: Previous data indicated that PRA responses in the pre-transplantation and the early post-transplantation periods correlate with kidney allograft rejection and that differences in PRA levels are associated with significant differences in graft rejection.
The aim of the Work: Aim of this study is to identify possible risk factors for sensitization that affect the PRA results.
Material and Methods: The present cross-sectional study was performed in 2010 on fifty ESRD patients (twenty five males and twenty five females) waiting kidney transplantation in King Fahd Unit, Cairo University and a Private Center in Egypt. All clinical and laboratory data were recorded, including PRA using complement dependent cytotoxicity using lympho-cytes. We tested the correlation between PRA and different variables. PRA results above 20% are considered positive, while results below 20% are considered negative.
Results: We found positive PRA in 12 cases (24%) in our study as the result is above 20% while 38 cases (76%) in our study are considered negative as PRA result below 20%.
Highly significant positive correlation between PRA levels and HCV positivity, history of renal transplantation and history of pregnancy. Subanalysis of HCV positive cases showed that blood transfusion was an essential finding in these patients. There was no statistically significant correlation between PRA and age, gender, BMI, etiology of renal failure, duration of renal failure or dialysis, blood group, blood or plasma transfusion, HBV, history of Rheumatoid arthritis, DM, HTN, SLE or history of drug intake.
Conclusion: This study found that the only factors that correlate with PRA are HCV positive cases (p<0.001), previous transplantation (p<0.001) and pregnancy history (p<0.001).