Serum Resistin as a Predictor of Outcome in Traumatic Head-Injured Patients in Intensive Care Unit of Suez Canal University Hospital
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- Category: Vol. 82, March 2014
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Serum Resistin as a Predictor of Outcome in Traumatic Head-Injured Patients in Intensive Care Unit of Suez Canal University Hospital, HOSSAM M. ATEF, EZZAT M. EL-TAHER, ALAA ELDIN M. AL-KASSABY and EMAN M. TEAMA
Abstract
Objective: To assess serum resistin levels as a predictor of outcome in ICU patients with traumatic head injuries at Suez Canal University Hospital, to improve outcomes in such patients.
Patients and Methods: In total, 48 patients with severe traumatic brain injury (TBI) were included. Plasma samples were obtained on admission and at days 3 and 5 after TBI. Resistin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Outcome (morbidity and mortality) was assessed at 14 days in the ICU using the Glasgow Outcome Scale (GOS).
Results: The mean age of the patients was 32.3±8.1 years; most were males (91.7%). The mean GOS on admission was 6/15. Most of the patients showed multiple findings on CT (58.3%). Twelve (25%) patients died. A multiple logistic regression model showed that GOS on admission <7/15, random blood sugar (RBS) on admission >200mg/dL, and bilateral non-reactive pupils in the assessment were significant predictors of 14-day mortality (ORs: 1.3, 1.9, and 1.69, respectively) and a resistin level on admission to the ICU of >0.618ng/mL was also a significant predictor of 14-day mortality (sensitivity of 100%, specificity of 77.8%, PPV of 60%, and a NPV of 100%).
Conclusions: Resistin may be useful as a novel biomarker in TBI as an adjuvant prognostic tool to predict poor outcome.