Macular Ganglion Cell Complex Measurement Using Spectral Domain Optical Coherence Tomography in Glaucoma
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- Category: Vol. 83, September 2015
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Macular Ganglion Cell Complex Measurement Using Spectral Domain Optical Coherence Tomography in Glaucoma, ZEINAB S. EL-SANABARY, KARIM A. RAAFAT, MOHAMED A. HASSABALLAH and NANCY Y. KHAIRAT
Abstract
Background: Glaucoma is a progressive optic neuropathy primarily damaging the ganglion cell complex and causing a gradual loss of ganglion cell axons. The FD-OCT offers com-prehensive glaucoma evaluation by providing assessment of RNFL thickness, optic disc morphology, and Ganglion Cell Complex (GCC) thickness, which is defined as the combination of nerve fiber, ganglion cell, and inner plexiform layers. In this study, we studied the diagnostic value of macular GCC thickness measurement in glaucoma suspects and in early to moderate glaucoma cases.
Methods: A total of 91 eyes were included in the study. The eyes of participants were classified into 3 groups: The control group (30 eyes), the glaucoma suspects group (31 eyes) and the early to moderate glaucoma group (30 eyes). All subjects underwent complete ophthalmic examination, gonioscopy, Goldmann applanation tonometry, corneal pa-chymetry, Visual field examination using standard automated perimetry performed with a Humphrey Field Analyzer using the Swedish Interactive Threshold Algorithm (SITA) standard strategy, program central 24-2 and imaging using FD-OCT; the RTVue-100 glaucoma protocol.
Results: GCC parameters significantly differentiated between controls and suspects and between controls and early glaucoma cases.
Conclusions: Macular GCC thickness is promising for detection of early and moderate glaucoma. However, further clinical evidence is needed to assess GCC role in detecting early glaucomatous damage.