Role of Interferon-Inducible Protein P56 in Lichen Planus, NAHLA HUNTAR, MOHAMED ELKOMY, DINA KADRY, RAGIA WESHAHY, WAFAA RASHEED and LAILA RASHED
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Role of Interferon-Inducible Protein P56 in Lichen Planus, NAHLA HUNTAR, MOHAMED ELKOMY, DINA KADRY, RAGIA WESHAHY, WAFAA RASHEED and LAILA RASHED
Abstract
Background: Lichen planus (LP) is an inflammatory disease of skin, nails, hair follicles and mucous membranes. Lichen planus is a disease of unknown etiology. Although, infections and stress has been suggested as a triggering factors. Virus infection or virus triggering the cytotoxic immune response in LP has been discussed. The Interferon (IFN) system is the first line of defense against virus infection. P56 is considered one of the significant IFN inducible proteins. It belongs to a family of structurally related proteins that are induced by viral stresses. Hepatitis C virus infection is asso-ciated with a statistically significant risk for development of LP. Lichen Planus appears to be related to the pattern of immune dysregulation induced by HCV rather than the type of virus itself. Thus, it is probable that other viral associations than HCV may exist in LP.
Objectives: The aim of this work is to detect the presence of interferon-induced protein (P56) in LP lesions, of non-hepatitic patients, and using it as a marker of viral infection, in order to detect a possible role of viral infection other than hepatitis c virus in the pathogenesis of LP.
Methods: The study included 34 patients with LP and 34 apparently healthy subjects as controls. From each patient and control one 4mm punch skin biopsy was be obtained and prepared for real time polymerase chain reaction (PCR) detection of P56 expression.
Results: Our results revealed that mean P56 levels were significantly higher in patients than controls.
Conclusion: This may implicate that a viral infection might play a role in the etiology of LP.