Hemodynamics and Respiratory Stability during Awake Craniotomy: Dexmedetomidine-Based Sedation Versus Propofol-Based Sedation, MOSTAFA M. ELADANY, FATMA M. KHAMIS, MAGDY A. OMERA, AMGAD A. MATAR and HOSSAM M. MOSTAFA
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- Category: Vol. 83, March 2015
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Hemodynamics and Respiratory Stability during Awake Craniotomy: Dexmedetomidine-Based Sedation Versus Propofol-Based Sedation, MOSTAFA M. ELADANY, FATMA M. KHAMIS, MAGDY A. OMERA, AMGAD A. MATAR and HOSSAM M. MOSTAFA
Abstract
Background: Awake craniotomy aims to remove most of the brain tumour while preserving the eloquent area of the brain, many factors affecting hemodynamics and respiration during awake craniotomy especially sedative drugs: Type and doses.
Aim: To detect hemodynamics and respiratory effects of dexmedetomidine-based sedation and propofol-based sedation in patients undergoing awake craniotomy for resection of brain tumours, which has encroachment on eloquent area of the brain.
Patients and Methods: Randomized, prospective, com-parative clinical trial study was carried out on 28 patients of both sexes undergoing elective surgery for brain tumor resec-tion in the routine surgical lists in Suez Canal University Hospital, from January 2012 to April 2014, patients are divided into two equal groups (14 patients): Propofol group and dexmedetomidine group.
Results: There were more hemodynamically stability and respiratory stability among dexmedetomidine group, there were statistically significant difference between the two groups in some time intervals.
Conclusions: Dexmedetomidine provide more hemody-namically stability and less effects on respiration during awake craniotomy.