Comparison between Dexmedetomidine-Based Sedation and Propofol-Based Sedation in Patients Undergoing Awake Craniotomy for Brain Tumor Resection
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- Category: Vol. 83, March 2015
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Comparison between Dexmedetomidine-Based Sedation and Propofol-Based Sedation in Patients Undergoing Awake Craniotomy for Brain Tumor Resection, MOSTAFA M. ELADANY, FATMA M. KHAMIS, MAGDY A. OMERA, AMGAD A. MATAR and HOSSAM M. MOSTAFA
Abstract
Background: Awake craniotomy enables the surgeon to resect the brain tumors maximally and preserve important functional areas of brain such as the motor, somatosensory and language areas, Dexmedetomidine, a highly selective a2- agonist with analgesic, sedative and anesthetic-sparing effects.
Aim: To Compare between dexmedetomidine-based seda-tion and propofol-based sedation as monitored anesthesia care for patients undergoing awake craniotomy for resection of low grade gliomas, meningiomas and metastases, which are adjacent to eloquent area of the brain.
Patients and Methods: Randomized, prospective, com-parative clinical trial study was carried out on 28 patients of both sexes undergoing elective surgery for brain tumor resec-tion in the routine surgical lists in Suez Canal University Hospital, from January 2012 to April 2014, patients are divided into two equal groups (14 patients): Propofol group and dexmedetomidine group.
Results: There were overall better revival quality in dexmedetomidine group with statistically significant faster arousal time after discontinuation of the sedative. There were no statistically significant differences between both studied groups regarding incidence of adverse events throughout the procedure.
Conclusions: Dexmedetomidine can be effectively and safely administered for conscious sedation in awake craniotomy with shorter arousal time and better quality of revival.