Progression, Treatment and Follow-Up of Laryngeal Amyloidosis: A Report of 4 Cases
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- Category: Vol. 83, March 2015
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Progression, Treatment and Follow-Up of Laryngeal Amyloidosis: A Report of 4 Cases, ALEXANDRA WECKEL, VIRGINIE WOISARD, SARAH ALSHEHRI and SEBASTIEN VERGEZ
Abstract
Background: Laryngeal amyloidosis is rare, representing 1% of benign tumors of the larynx. It is usually a localized amyloid light-chain (AL) amyloidosis. The most common symptom is dysphonia hoarseness.
Aim of Study: To report the four cases who presented with laryngeal amyloidosis and to describe their outcomes during a long-term follow-up. Each patient underwent at least one surgical procedure for this condition. The entire amyloid tissue was completely excised in only one case without recurrence. In the three other cases, the lesion increased slowly in the larynx. An extension into the trachea was observed in one case. In conclusion, laryngeal amyloidosis is a benign disease, but its location within the larynx may be associated with functional impairment in terms of phonation, swallowing and breathing. To improve function, the treatment of this evolutive disease may involve surgical removal (complete or incomplete), radiation therapy or simple follow-up.
Conclusions: Laryngeal amyloidosis is difficult to cure while preserving laryngeal function. Regular laryngoscopic follow-up is justified due to the potential of recurrence. Multiple surgical procedures may be required and may be combined with other therapeutic modalities, including new radiation therapy techniques. However, long-term follow-up for at least 10 years is fundamental not only because of the recurrence but also because of the possible development of systemic disease.