Evaluation of Left Ventricular Scar Burden on Outcome of Cardiac Resynchronization Therapy
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- Category: Vol. 84, June 2016
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Evaluation of Left Ventricular Scar Burden on Outcome of Cardiac Resynchronization Therapy, WALID AHMED, WAEL SAMY, OSAMA TAYEH, NOHA BEHAIRY and ALIA ABD EL-FATTAH
Abstract
Background: Scar burden assessment could help in tailor-ing better response to Cardiac Resynchronization Therapy (CRT).
Methods: Thirty patients underwent CRT implantation. Pre-implantation Cardiac Magnetic Resonance (CMR) with late gadolinium enhancement technique to examine LV scar burden.
Results: Thirty patients received CRT (mean age 58.7±9.0, 24 males). CRT implantation showed functional improvement in form of reverse LV remodeling (³15%), which was docu-mented in 19 patients. Applying ROC for predicting CRT non-response, showed a cutoff 36.5% for global LV scar burden had a sensitivity of 81.8% and specificity of 68.4%. a cutoff 4.5 segments with scar thickness ³50% of whole segment thickness had a sensitivity of 81.8% and specificity of 63.2%. A cutoff 12% for lateral wall scar burden had a sensitivity of 81.8% and specificity of 68.4%.
Conclusion: LV scar had unfavorable impact on CRT response. Both global and lateral wall scar burden, extent could predict CRT non-response status.