Early Detection of Gestational Diabetes Via Measurement of First Trimester Maternal Serum Uric Acid, NADER
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- Category: Vol. 84, June 2016
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Early Detection of Gestational Diabetes Via Measurement of First Trimester Maternal Serum Uric Acid, NADER A. ABO HASSAN, AHMED Y. REZK, KHALED M. SALAMA and MOSTAFA A. ELSAYED
Abstract
Rational and Background: Diabetes is the most common medical complication of pregnancy. It occurs in between 5 and 10% of all pregnancies. In pregnancy, uric acid is correlated with insulin resistance in women with gestational hypertension and is higher at 24-28 weeks gestation in women diagnosed with GDM compared to women without diabetes.
Objectives: To find out if the elevated first trimester uric acid is associated with development of gestational diabetes mellitus.
Study Design: This prospective observational study was conducted in Damnhour Educational Hospital Department of Obstetrics and Gynaecology, between March 2015 and No-vember 2015. A total of 80 pregnant women (<13 weeks gestation) were included in the study. Baseline assessments included age, BMI, parity, number of previous abortions and serum uric acid level. Subjects were re-assessed at 24-28 weeks for Gestational Diabetes Mellitus (GDM). Data was systematically recorded and analysed to test for associations of various parameters with GDM.
Results: Elevated first-trimester uric acid concentration was correlated with an increased risk of developing GDM. The risk of developing GDM was higher if first-trimester uric acid was ³3.11mg/dl [OR 6.11, 95% CI (2.33 to 8.11)]. Also There was a significant positive correlation between serum uric acid and BMI (r=0.66, p-0.008). The mean BMI was significantly higher in women who developed GDM when compared to women who did not develop GDM [29.23±3.11 Kg/m2 vs. 27.8±3.97Kg/m2, respectively, p-0.021].
Conclusions: Serum uric acid elevation in first trimester has a significant correlation with development of gestational diabetes mellitus.