Lack of Association between Interleukin-1b Gene Polymorphisms and Alopecia Areata; A Case Control Study
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- Category: Vol. 84, June 2016
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Lack of Association between Interleukin-1b Gene Polymorphisms and Alopecia Areata; A Case Control Study, EMAN SHAARAWY, RANIA ABD EL-HAY, NESRINE SAMIR, MERVAT KHORSHIED, HEBA GOUDA, IMAN HELWA and YASMIN B. EL-ZAWAHRY
Abstract
Background: Alopecia Areata (AA) is an autoimmune disease characterized by T-cell infiltrates and cytokine pro-duction around anagen hair follicles. The aetiology of AA includes genetic susceptibility, environmental and immuno-logical factors.
Objective: To study the possible association of IL-1b-C-511T and C+3953T Single Nucleotide Polymorphism (SNP) with AA.
Methods: This case-control study was conducted on 100 AA patients and 100 controls. Three ml venous blood was withdrawn from every participant for genotyping of IL-1B-511 C/T, and IL-1B +3954 C/T SNPs using PCR-RFLP tech-nique.
Results: The studied genotype distribution and allele frequencies showed no significant difference between AA patients and healthy controls, apart from IL-1b+3953 C allele that was found more frequently than T allele among cases and controls.
Conclusion: IL-1b C-511T and C+3953T SNPs have no etiological role in our studied Egyptian AA patients.