b-Catenin Expression in Colorectal Carcinoma
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- Category: Vol. 84, June 2016
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b-Catenin Expression in Colorectal Carcinoma, SAMAR A. EL-SHEIKH, AMIRA M. BASSAM and HEBA A. IBRAHIM
Abstract
Background: Colorectal cancer is one of the leading causes of cancer death in both developed and developing nations. Therefore, identification of clinicopathological prognostic factors associated with tumor growth, invasion and metastasis has been critical to develop potential therapeutic interventions. Tumor budding is a high-grade undifferentiated component of a tumor at the leading invasive edge as small clusters (<5) or single infiltrating tumor cells.
Aim: To assist the immunohistochemical expression pattern of b-catenin and correlate with other clinicopathological parameters.
Material and Methods: 50 cases of colorectal carcinoma, two sections were prepared from each block, one stained with (H & E) and the other was subjected to the immunohistochem-ical marker (b-catenin).
Results: The current study included fifty cases of colorectal carcinomas studied immunohistochemically for b-catenin expression. b-catenin expression was positive in 34% of cases. There was no statistical relationship between b-catenin ex-pression and different clinicopathological findings, except when associated with concomitant budding and lymph node metastasis.
Conclusion: This study suggests that tumor budding might play a role in the ability of colon cancer cells to invade and metastasize and thusmay be used as a prognostic marker to predict poor outcome of patients and a scoring system for pathological reporting of tumor budding may be beneficial. It will be necessary to carry out similar studies on a larger sample size to predict the possible prognostic significance of b-catenin.